The cutaneous-neuro-inmuno System (CNIS) is a novel concept of cutaneous biology. States the importance of the Nervous System and the psyquism at the cutaneous homeostasis. Solving cosmetic problems of the skin is now achievable when interacting with the Cutaneous Nervous System.

The neuropeptides or "intelligent cosmetic" consist of the application of topic administration of synthetic neuropeptides whose neurophysiologic action performs cosmetic and esthetic benefits as well as wellness benefits.